| IIT - Gozzi Lab |
My laboratory at the Istituto Italiano di Tecnologia uses advanced tools like https://www.nature.com/articles/s41467-024-52721-8, functional ultrasound imaging (fUSI), optogenetics, https://www.nature.com/articles/s41467-022-28591-3, electrophyiology and https://www.sciencedirect.com/science/article/pii/S0960982221016912 to map and manipulate brain network activity in the mouse. Crucially, the use of non-invasive functional imaging methods like fMRI enable us to translate findings between https://www.nature.com/articles/s41467-021-26131-z. Supported by two back-to-back European Research Council (ERC) grants (https://cordis.europa.eu/project/id/802371 https://erc.europa.eu/sites/default/files/2023-11/erc-2023-cog-results-all-domains.pdf), our work seeks to understand the fundamental principles governing brain network activity, and its https://youtu.be/u_eCliKjnhkin developmental disorders like autism. |
Behavior, Chemogenetic, Functional Connectivity, Mouse, Optogenetic, ePhys, fMRI, fUSI |
https://www.iit.it/it/web/functional-neuroimaging |
| INSERM - Lenkei Lab |
The team’s previous projects were mainly focused to decipher the closely intertwined relationship between cannabinoid receptor activation and sub-neuronal targeting, by using quantitative in vitro imaging approaches of neurons. In the last years, we became increasingly interested in the understanding of cannabinoid-mediated regulation of neuronal structure. Established techniques range from molecular constructions through imaging-based measurements of GPCR activation in cultured hippocampal neurons to the use of animal models of cerebral plasticity. Current projects of the team are targeted to develop and use new tools to better understand, at multiple spatio-temporal scales, the role of the highly dynamic actomyosin cytoskeleton in neuronal function and neuropsychiatric pathogenesis. One of this new tools, Ultrafast functional Ultrasound (fUS) imaging, also revealed itself as highly adapted to access nervous system function through imaging the neurovascular coupling, so an important part of our current efforts is focused to further develop this powerful tool either in collaborative projects or in-house, the latter focused on imaging the functional consequences of actomyosin remodeling on brain structure and connectivity. |
Functional Connectivity, Mouse, fUSI, pharmacology |
https://ipnp.paris5.inserm.fr/research/teams-and-projects/21-team-lenkei |